BDBM50095495 CHEMBL262697::Pyrrolidine-1-carbonitrile

SMILES N#CN1CCCC1

InChI Key InChIKey=QJRYYOWARFCJQZ-UHFFFAOYSA-N

Data  1 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50095495   

TargetCathepsin K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition constant against human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of human recombinant cathepsin K after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProcathepsin L(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibition of human recombinant cathepsin L after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibition of human recombinant cathepsin S after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50: >2.51E+4nMAssay Description:Inhibition of human recombinant cathepsin B after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  3.40E+3nMpH: 7.0Assay Description:Effect of 10 mM of GSH on the inhibitory activity against Cathepsin K, at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibitory activity tested against Human Cathepsin B using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  1.63E+3nMpH: 5.5Assay Description:Inhibition of Cathepsin K at pH 5.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  2.30E+3nMpH: 7.0Assay Description:Inhibition of Cathepsin K at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProcathepsin L(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity tested against Human Cathepsin L using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity tested against Human Cathepsin K using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory concentration against human cathepsin K using 10 uM Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDipeptidyl peptidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50: >2.51E+4nMAssay Description:Inhibition of human recombinant cathepsin C after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50095495(CHEMBL262697 | Pyrrolidine-1-carbonitrile)
Affinity DataIC50:  1.50E+3nMpH: 5.5Assay Description:Effect of 10 mM of GSH on the inhibitory activity of compound against Cathepsin K, at pH 5.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed