BDBM50103506 Ranitidine::Tritec::Zantac

SMILES CNC(NCCSCc1ccc(CN(C)C)o1)=C[N+]([O-])=O

InChI Key InChIKey=VMXUWOKSQNHOCA-UKTHLTGXSA-N

Data  1 KI  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50103506   

TargetHistamine H2 receptor(Guinea pig)
Freie Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataKi:  54nMAssay Description:Inhibition of [125I]APT binding to histamine H2 receptor in guinea pig cerebral membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2J2(Human)
Tongji University

Curated by ChEMBL
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Guinea pig)
Freie Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataIC50:  3.33E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Human)TBA
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataKd:  63nMAssay Description:Binding affinity to histamine H2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetBile salt export pump(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed