BDBM50103636 ADD-3878::CHEBI:64227::Ciglitazone::U-63287

SMILES CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1

InChI Key InChIKey=YZFWTZACSRHJQD-UHFFFAOYSA-N

Data  8 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50103636   

TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataEC50:  1.41E+4nMAssay Description:Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataEC50:  4.50E+3nMAssay Description:Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center

Curated by ChEMBL
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataEC50:  1.00E+4nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataIC50:  3.78E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataIC50:  2.70E+3nMAssay Description:Antagonist activity at 15-PGDH (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataIC50:  3.78E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataIC50: >5.00E+3nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataEC50:  3.00E+3nMAssay Description:Transactivation activity at Homo sapiens (human) PPARgammaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAmine oxidase [flavin-containing] B(Human)
Comsats University Islamabad

Curated by ChEMBL
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataIC50:  225nMAssay Description:Inhibition of recombinant human MAO-BMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed