BDBM50105089 8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL326962

SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccc3OCOc3c2)CC1

InChI Key InChIKey=HWOUIMXZGKRMNK-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50105089   

TargetDelta-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105089(8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaz...)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of ligand binding to human delta opioid receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105089(8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaz...)
Affinity DataIC50:  1.19E+3nMAssay Description:Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105089(8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaz...)
Affinity DataIC50:  56nMAssay Description:Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105089(8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaz...)
Affinity DataIC50:  17nMAssay Description:Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105089(8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaz...)
Affinity DataIC50:  17nMAssay Description:Binding affinity against mu opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105089(8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaz...)
Affinity DataIC50:  947nMAssay Description:Inhibition of human dopamine receptor D4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105089(8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaz...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105089(8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaz...)
Affinity DataIC50:  340nMAssay Description:Inhibition of human ORL1 orphanin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105089(8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaz...)
Affinity DataIC50:  56nMAssay Description:Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM50105089(8-Benzo[1,3]dioxol-5-ylmethyl-1-phenyl-1,3,8-triaz...)
Affinity DataIC50:  557nMAssay Description:Inhibition of human dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed