BDBM50108299 CHEMBL288229::Indolocarbazole analogue

SMILES CCSCc1ccc2n3c4c(c5CNC(=O)c5c5c6ccccc6n([C@H]6C[C@](O)(C(=O)OC)[C@]3(C)O6)c45)c2c1

InChI Key InChIKey=UFLRHQRKTYVKGB-YCIRJXQPSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50108299   

TargetMitogen-activated protein kinase kinase kinase 10(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50108299(CHEMBL288229 | Indolocarbazole analogue)
Affinity DataIC50:  28nMAssay Description:Inhibition of Mixed lineage kinase 2(MLK2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50108299(CHEMBL288229 | Indolocarbazole analogue)
Affinity DataIC50:  61nMAssay Description:Inhibition of NGF high affinity receptor tyrosine kinase TrkAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50108299(CHEMBL288229 | Indolocarbazole analogue)
Affinity DataIC50:  400nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50108299(CHEMBL288229 | Indolocarbazole analogue)
Affinity DataIC50:  28nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50108299(CHEMBL288229 | Indolocarbazole analogue)
Affinity DataIC50:  21nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed