BDBM50115301 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide::CHEMBL102346

SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC

InChI Key InChIKey=INTPTKHSGKBHHW-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50115301   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  230nMAssay Description:Inhibition of Flt3 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMast/stem cell growth factor receptor Kit(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor alpha(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Platelet-derived growth factor receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  80nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor beta(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  130nMAssay Description:Inhibition of Platelet-derived growth factor receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor beta(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor beta(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >80nMAssay Description:Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlatelet-derived growth factor receptor beta(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50:  80nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115301(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed