BDBM50118955 CHEMBL94678::Compound K-252a(epi)

SMILES COC(=O)[C@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13

InChI Key InChIKey=KOZFSFOOLUUIGY-BLIZRMSTSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50118955   

TargetHigh affinity nerve growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50118955(CHEMBL94678 | Compound K-252a(epi))
Affinity DataIC50:  1.20nMAssay Description:Inhibition of nerve growth factor receptor, trkAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50118955(CHEMBL94678 | Compound K-252a(epi))
Affinity DataIC50:  25nMAssay Description:Inhibition of Myosin light chain kinase 1 (MLCK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118955(CHEMBL94678 | Compound K-252a(epi))
Affinity DataIC50:  19nMAssay Description:Inhibition of VEGF-receptor 2 (KDR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50118955(CHEMBL94678 | Compound K-252a(epi))
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of PKCtheta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50118955(CHEMBL94678 | Compound K-252a(epi))
Affinity DataIC50:  5nMAssay Description:Inhibition of NGF-stimulated TrkA phosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50118955(CHEMBL94678 | Compound K-252a(epi))
Affinity DataIC50:  1.20nMAssay Description:Inhibition of baculovirus expressed human trkAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed