BDBM50130665 (RS)-{4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridin-2-yl}-(1-phenylethyl)amine]::4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)-N-(1-phenylethyl)pyridin-2-amine::CHEMBL111364::ML-3403::{4-[5-(4-Fluoro-phenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenyl-ethyl)-amine

SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NC(C)c2ccccc2)c1

InChI Key InChIKey=VXPWQNBKEIVYIS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50130665   

TargetMitogen-activated protein kinase 14(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50130665((RS)-{4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-im...)
Affinity DataIC50:  380nMAssay Description:Inhibition of p38alphaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130665((RS)-{4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-im...)
Affinity DataIC50:  990nMAssay Description:Inhibition of p38-related IL1-beta release by whole blood cells at 10 e-4 to 10 e-8 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130665((RS)-{4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-im...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of p38-related TNF-alpha release by whole blood cells at 10 e-4 to 10 e-8 MMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130665((RS)-{4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-im...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against induction of IL-1-beta release in PBMCsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130665((RS)-{4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-im...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity against TNF-alpha release in PBM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50130665((RS)-{4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-im...)
Affinity DataIC50:  380nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 at 10 e-4 to 10 e-8 M concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed