BDBM50170284 GSK2141795::GSK2141795C::Uprosertib

SMILES Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@H](CN)Cc1ccc(F)c(F)c1

InChI Key InChIKey=AXTAPYRUEKNRBA-JTQLQIEISA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50170284   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  18nMAssay Description:Inhibition of Akt1 (unknown origin) expressed in Escherichia coli using peptide substrate after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of Akt1 (unknown origin) expressed in Escherichia coli using peptide as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  60nMAssay Description:Inhibition of human P70S6K by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  125nMAssay Description:Inhibition of human ROCK1 by mobile shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of Akt3 (unknown origin) by mobile shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of choline acetyltransferase (ChAT) activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  211nMAssay Description:Inhibition of human SGK by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  339nMAssay Description:Inhibition of RSK1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  0.0660nMAssay Description:Inhibition of choline acetyltransferase (ChAT) activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of choline acetyltransferase (ChAT) activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Akt2 by mobile shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed