BDBM50173335 CHEBI:87690::CVT-303::RS-43285-003::Ranexa::Ranolazine

SMILES COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1

InChI Key InChIKey=XKLMZUWKNUAPSZ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50173335   

TargetVoltage-gated sodium channel Nav1.5 cardiac isoform(Canis lupus familiaris)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173335(CHEBI:87690 | CVT-303 | RS-43285-003 | Ranexa | Ra...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of canine ventricular myocytes Nav 1.5 assessed as reduction in ATX-2 induced late channel current by manual single-patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50173335(CHEBI:87690 | CVT-303 | RS-43285-003 | Ranexa | Ra...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin)-mediated late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173335(CHEBI:87690 | CVT-303 | RS-43285-003 | Ranexa | Ra...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human ERG expressed stably in CHO cells by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed