BDBM50178769 (+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide::6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide::CHEMBL420311
SMILES NC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
InChI Key InChIKey=FUZYTVDVLBBXDL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 54 hits for monomerid = 50178769
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataKi: 114nMAssay Description:Uncompetitive inhibition of His6-tagged SIRT1 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant measured ever...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 1.28E+5nMAssay Description:Inhibition of catalytically active human SIRT3 (102 to 399 amino acids) expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-me...More data for this Ligand-Target Pair
3D Structure (crystal)TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.96E+4nMAssay Description:Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 98nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 98nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
Elixir Pharmaceuticals
Curated by ChEMBL
Elixir Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against pig brain NAD glycohydrolase (NADase) by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 4.87E+4nMAssay Description:Inhibitory activity against recombinant human SIRT3 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of His-tagged human recombinant SIRT2 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of His-tagged human recombinant SIRT1 expressed in Escherichia coli using Cbz-Lys(Ac)-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) preincubated for 5 mins before addition of substrate measured after 1 hr by fluorescence-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) preincubated for 5 mins before addition of substrate measured after 3 hrs by fluorescence-based assa...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant GST-tagged SIRT1 expressed in 293T cells by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.96E+4nMAssay Description:Inhibition of human recombinant GST-tagged SIRT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.85E+4nMAssay Description:Inhibition of human recombinant SIRT2 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of SIRT1 using p53-based 18mer as substrateMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of SIRT1 using Ac-His-Arg-Lys-Lys(Ac)-AMC as substrateMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of SIRT1 by high throughput screening assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli cells using acetylated Lys side chain amino acids 379-382 (Arg-His-Lys-Lys(Ac)) p...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 s...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibition of recombinant SIRT3 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 2.01E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant His-tagged full-length Sirt1 expressed in Escherichia coli BL21 DE3 Rosetta2 using acetyl-p53-peptide as substrate by...More data for this Ligand-Target Pair
Affinity DataIC50: 1.96E+4nMAssay Description:Inhibition of recombinant human full length SIRT2 using fluorescent ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of recombinant human N-tagged GST-SIRT1 fusion protein using fluorescent ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetyl...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of human SIRT1 deacetylase activity using acetylated H3K9 as substrate preincubated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged/SUMO-fused SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 assessed as reduction...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 2.54E+4nMAssay Description:Inhibition of human N-terminal His-tagged SIRT3 (122 to 391 residues) expressed in Escherichia coli using Ac-Tyr-Lys-Leu-Lys(Ac)-AMC as substrate pre...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Xihua University
Curated by ChEMBL
Xihua University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human N-terminal His-tagged SIRT5 (34 to 302 residues) expressed in Escherichia coli using Ac-Tyr-Lys-Leu-Lys(Ac)-AMC as substrate prei...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Xihua University
Curated by ChEMBL
Xihua University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human N-terminal His-tagged SIRT5 (34 to 302 residues) expressed in Escherichia coli using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate prei...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human N-terminal His-tagged SIRT1 (183 to 664 residues) expressed in Escherichia coli using Ac-Arg-Leu-Ile-Lys(Ac)-AMC as substrate pre...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human N-terminal His-tagged SIRT1 (183 to 664 residues) expressed in Escherichia coli using Ac-Tyr-Lys-Leu-Lys(Ac)-AMC as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 (56 to 356 residues) expressed in Escherichia coli using Ac-Arg-Leu-Ile-Lys(Ac)-AMC as substrate prei...More data for this Ligand-Target Pair
Affinity DataIC50: 5.24E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 (56 to 356 residues) expressed in Escherichia coli using Ac-Ser-Ser-Ile-Lys(De)-AMC as substrate prei...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 8.21E+4nMAssay Description:Inhibition of human N-terminal His-tagged SIRT3 (122 to 391 residues) expressed in Escherichia coli using Ac-Arg-Leu-Ile-Lys(Ac)-AMC as substrate pre...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 690nMAssay Description:Inhibition of recombinant human SIRT1 (193 to 741 residues) expressed in Escherichia coli expression system using RHKK(Ac)W-NH2 as substrate measured...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human SIRT2 expressed in baculovirus infected SF9 cells expression system using RHKK(Ac)W-NH2 as substrate measured after 2...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Max Planck Institute of Molecular Physiology
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of His6-tagged SIRT1 (unknown origin) expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins followed by NAD+ addition and meas...More data for this Ligand-Target Pair