BDBM50182571 2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan-1-one::CHEMBL369997

SMILES CCCC(N1CCCC1)C(=O)c1ccc(cc1)-c1cccs1

InChI Key InChIKey=HEFDYDISPNHKAM-UHFFFAOYSA-N

Data  3 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50182571   

LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataKi:  370nMAssay Description:Displacement of [125I]RTI-55 from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent dopamine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataKi:  460nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent serotonin transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataKi:  3.32E+3nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2C(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against 5HT1CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1B(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against 5HT1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(1A) dopamine receptor(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against dopamine D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent dopamine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataIC50:  539nMAssay Description:Inhibition of [3H] dopamine uptake into human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataIC50:  263nMAssay Description:Inhibition of [3H] norepinephrine uptake into human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against dopamine D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent serotonin transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataIC50:  1.96E+3nMAssay Description:Inhibition of [3H] serotonin uptake into human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1A(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against 5HT1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50182571(2-pyrrolidin-1-yl-1-(4-thiophen-2-yl-phenyl)pentan...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against dopamine D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed