BDBM50182694 CHEMBL202398::N-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolinyl]-4-(dibutylamino)-2-butynamide

SMILES CCCCN(CCCC)CC#CC(=O)Nc1ccc2ncnc(Nc3ccc(F)c(Cl)c3)c2c1

InChI Key InChIKey=JCUNURGXJBYRFK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50182694   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182694(CHEMBL202398 | N-[4-[(3-chloro-4-fluorophenyl)amin...)
Affinity DataIC50:  464nMAssay Description:Inhibition of erbB2 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182694(CHEMBL202398 | N-[4-[(3-chloro-4-fluorophenyl)amin...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EGF stimulated human erbB1 autophosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182694(CHEMBL202398 | N-[4-[(3-chloro-4-fluorophenyl)amin...)
Affinity DataIC50:  624nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182694(CHEMBL202398 | N-[4-[(3-chloro-4-fluorophenyl)amin...)
Affinity DataIC50:  32nMAssay Description:Inhibition of HER stimulated human erbB autophosphorylation in MDA-MB-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182694(CHEMBL202398 | N-[4-[(3-chloro-4-fluorophenyl)amin...)
Affinity DataIC50:  40nMAssay Description:Inhibition of erbB1 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed