BDBM50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine
SMILES OC[C@H]1CNC[C@@H](O)[C@@H]1O
InChI Key InChIKey=QPYJXFZUIJOGNX-HSUXUTPPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50182801
Affinity DataKi: 1.70nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 1.70nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of Agrobacterium sp. beta-glucosidaseMore data for this Ligand-Target Pair
TargetGlycogen phosphorylase, muscle form(Rabbit)
The National Hellenic Research Foundation
Curated by ChEMBL
The National Hellenic Research Foundation
Curated by ChEMBL
Affinity DataKi: 5.20E+3nMAssay Description:Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase in presence of phosphateMore data for this Ligand-Target Pair
TargetTrehalose synthase/amylase TreS(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of British Columbia
University of British Columbia
Affinity DataKi: 1.40E+5nMAssay Description:The inhibition of TreS by a range of known alpha-glucosidase inhibitor was assayed.More data for this Ligand-Target Pair
Affinity DataKi: 9.00E+6nM ΔG°: -2.90kcal/molepH: 5.6 T: 37°CAssay Description:Putative mannosidase assay using wild-type protein Btman2A. Enzyme inhibition assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+5nMAssay Description:Inhibition of rat intestinal isomaltase assessed as production of p-nitrophenol at by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5.31E+5nMAssay Description:Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of bovine liver beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of GCase in patient derived fibroblast cells using 5'pentafluorobenzoylaminofluorescein-di-beta-D-glucoside as substrate assessed as subst...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human lysosomal beta-glucosidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+5nMAssay Description:Inhibition of rabbit muscle amylo-1,6-glucosidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of liver glycogen phosphorylase AMore data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of beta-galactosidase derived from human peripheral blood mononuclear cell lysate using 4-methylumbelliferyl beta-D-galactopyranoside as s...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of beta-glucosidase derived from human peripheral blood mononuclear cell lysate using 4-methylumbelliferyl beta-D-glucopyranoside as subst...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human GCase assessed as reduction of 4-methylumbelliferone liberation using 4-methylumbelliferyl-beta-glucopyranoside as substrate prei...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMAssay Description:Chaperone activity at GCase N370S GBA mutant in patient derived fibroblast cell using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate assess...More data for this Ligand-Target Pair
Affinity DataEC50: 390nMAssay Description:Chaperone activity at GCase N370S GBA mutant in patient derived fibroblast cell assessed as GCase level incubated for 5 days by immunocytochemistry a...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant GCase (unknown origin) using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate at pH 4.5More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of rat intestinal lactase assessed as production of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of GCase assessed as 4-methylumbelliferone release assay after 30 mins by fluorimetryMore data for this Ligand-Target Pair
TargetGlycogen phosphorylase, muscle form(Rabbit)
The National Hellenic Research Foundation
Curated by ChEMBL
The National Hellenic Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylaseMore data for this Ligand-Target Pair
Affinity DataIC50: 670nMAssay Description:Inhibition of phosphorylated form of pig liver glycogen phosphorylaseMore data for this Ligand-Target Pair
TargetGlycogen phosphorylase, muscle form(Rabbit)
The National Hellenic Research Foundation
Curated by ChEMBL
The National Hellenic Research Foundation
Curated by ChEMBL
Affinity DataIC50: 760nMAssay Description:Inhibition of phosphorylated form of rabbit muscle glycogen phosphorylaseMore data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Rat)
The National Hellenic Research Foundation
Curated by ChEMBL
The National Hellenic Research Foundation
Curated by ChEMBL
Affinity DataIC50: 680nMAssay Description:Inhibition of phosphorylated form of rat liver glycogen phosphorylaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair