BDBM50199522 (+)-huperzine A::(+-)-HA::(-)-1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one(Huperzine A)::(-)-huperazine A::(-)-huperzine A::(-)1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one( (-)-Huperzine A)::(1R,9R)-1-Amino-13-eth-(E)-ylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::(R)-1-Amino-13-eth-(E)-ylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::(R)-1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::(huperazine A)(-)-1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::1-Amino-13-eth-(E)-ylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::1-Amino-13-eth-(Z)-ylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one((+/-)-Huperzine A)::1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one((-)-Huperzine A)::1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0~2,7~]trideca-2(7),3,10-trien-5-one::CHEMBL395280::HUPERAINE A::Hyperazzine A

SMILES C\C=C1/[C@@H]2Cc3[nH]c(=O)ccc3[C@@]1(N)CC(C)=C2

InChI Key InChIKey=ZRJBHWIHUMBLCN-YQEJDHNASA-N

Data  43 IC50  1 Kd

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 50199522   

TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  72.4nMpH: 5.0Assay Description:Inhibition of AChE in rat cortex at pH 5More data for this Ligand-Target Pair
TargetCholinesterase(Human)
Hebei University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of BuChE (unknown origin) using butyrylthiocholine iodide as substrate by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Bovine)
Università

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  74nMAssay Description:Inhibition of bovine AChE by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human acetylcholinesterase after 30 mins by microplate reader-based Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Pacific electric ray)
The Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  11.4nMAssay Description:Inhibition of Torpedo california AChE by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human AChE by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of AChE by Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Human)
Hebei University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of butyrylcholinesterase (BChE) in human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bovine)
Università

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  74nMAssay Description:Compound was evaluated for the inhibition of acetylcholinesterase of bovine erythrocytesMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  260nMAssay Description:Inhibition of acetylcholinesterase isolated from Human erythrocytes.More data for this Ligand-Target Pair
TargetCholinesterase(Human)
Hebei University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of butyrylcholinesterase (BChE) activity in human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bovine)
Università

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  74nMAssay Description:Inhibition of acetylcholinesterase (AChE)activity in bovine erythrocytesMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bovine)
Università

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  74nMAssay Description:In vitro inhibitory concentration against bovine acetylcholinesterase enzymeMore data for this Ligand-Target Pair
TargetCholinesterase(Human)
Hebei University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory concentration against BChE of human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  260nMAssay Description:In vitro inhibitory concentration against acetylcholinesterase of human erythrocytesMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  53nMAssay Description:In vitro inhibitory concentration against rat cortex acetylcholinesteraseMore data for this Ligand-Target Pair
TargetCarboxylic ester hydrolase(Rat)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  5.62E+4nMAssay Description:In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Human)
Hebei University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against human plasma ButyrylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  47nMAssay Description:Inhibitory concentration against human erythrocyte AcetylcholinesteraseMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bovine)
Università

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  53nMAssay Description:Inhibition of bovine acetylcholinesteraseMore data for this Ligand-Target Pair
TargetCholinesterase(Human)
Hebei University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human serum BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human erythrocyte AChEMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bovine)
Università

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  74nMAssay Description:Inhibition of bovine erythrocyte AChEMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  65nMAssay Description:Inhibition of AChE in Sprague-Dawley rat cortices using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  45nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  82nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate measured after 20 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  120nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rat)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  3.64E+4nMAssay Description:Inhibition of rat serum BChE using butyrylthiocholine iodide as substrate after 20 mins by by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  120nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 20 mins by by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  400nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  98nMAssay Description:Inhibition of AChE in rat cortex homogenate using acetylthiocholine iodide as substrate after 20 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetCarboxylic ester hydrolase(Rat)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  3.64E+4nMAssay Description:Inhibition of BuChE in rat serum using butyrylthiocholine iodide as substrate after 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetCholinesterase(Human)
Hebei University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  5.17E+3nMAssay Description:Inhibition of Electric eel AChE using acetylcholine iodide as substrate by spectrophotometry based Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Dog)
Hebei University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of dog serum BChE using butrylthiocholine iodide as substrate by spectrophotometry based Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rat)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  7.44E+4nMAssay Description:Inhibition of rat cortex homogenate BuChE by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  82nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase by spectrophotometric methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bovine)
Università

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  100nMAssay Description:Inhibition of bovine erythrocytes AChE using acetylthiocholine iodide as substrate incubated for 15 to 20 mins by Ellman's methodsMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataKd:  17nMAssay Description:Binding affinity to CM5 sensor chip immobilized recombinant human AChE assessed as dissociation constant at 298.15 K by surface plasmon resonance ass...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electric eel)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as a substrate incubated for 20 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
Fujian Normal University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  5.28E+3nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
TargetCarboxylic ester hydrolase(Rat)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  7.02E+4nMAssay Description:Inhibition of BuChE in rat serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed