BDBM50203065 3-phenylacrylaldehyde::3-phenylprop-2-enal::CHEMBL293492::cinnamaldehyde::trans-cinnamaldehyde

SMILES O=C\C=C\c1ccccc1

InChI Key InChIKey=KJPRLNWUNMBNBZ-QPJJXVBHSA-N

Data  8 IC50  6 EC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50203065   

LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataEC50:  5.14E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate countMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division protein FtsZ(Escherichia coli (strain K12))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataIC50:  6.86E+3nMAssay Description:Inhibition of Escherichia coli FtsZ polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division protein FtsZ(Escherichia coli (strain K12))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataIC50:  5.81E+3nMAssay Description:Inhibition of Escherichia coli FtsZ GTPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(White button mushroom)
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataIC50:  5.20E+5nMAssay Description:Inhibition of mushroom tyrosinase after 10 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataIC50: >5.00E+5nMAssay Description:Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellula...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataIC50: >5.00E+5nMAssay Description:Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced intracellul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
School of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataEC50:  1.90E+4nMAssay Description:Activation of TRPA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataEC50:  6.50E+3nMAssay Description:Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Human)
National Institute of Medicinal Materials

Curated by ChEMBL
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataIC50:  5.90E+4nMAssay Description:Inhibition of xanthine oxidase- mediated uric acid formation after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataEC50:  9.00E+3nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataEC50:  8.51E+3nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataEC50:  6.10E+4nMAssay Description:Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataIC50:  2.45E+5nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed