BDBM50208612 (-)-kurarinone::(2S)-2-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-8-(5-methyl-2-(prop-1-en-2-yl)hex-4-enyl)chroman-4-one::CHEMBL243796::kurarinone

SMILES [#6]-[#8]-c1cc(-[#8])c(-[#6]-[#6](-[#6]\[#6]=[#6](\[#6])-[#6])-[#6](-[#6])=[#6])c2-[#8]-[#6@@H](-[#6]-[#6](=O)-c12)-c1ccc(-[#8])cc1-[#8]

InChI Key InChIKey=LTTQKYMNTNISSZ-KESSSICBSA-N

Data  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50208612   

TargetBeta-secretase 1(Human)
Gyeongsang National University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50208612((-)-kurarinone | (2S)-2-(2,4-dihydroxyphenyl)-7-hy...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 2(Human)
Nippon Suisan Kaisha

Curated by ChEMBL
LigandPNGBDBM50208612((-)-kurarinone | (2S)-2-(2,4-dihydroxyphenyl)-7-hy...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human SGLT2 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/glucose cotransporter 1(Human)
Nippon Suisan Kaisha

Curated by ChEMBL
LigandPNGBDBM50208612((-)-kurarinone | (2S)-2-(2,4-dihydroxyphenyl)-7-hy...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of human SGLT1 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSterol O-acyltransferase 1(Human)
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50208612((-)-kurarinone | (2S)-2-(2,4-dihydroxyphenyl)-7-hy...)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibition of human macrophage ACAT expressed in human HepG2 cells using [14C]oleoyl-CoA as substrate incubated for 20 mins prior to substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyphenol oxidase 2(White button mushroom)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50208612((-)-kurarinone | (2S)-2-(2,4-dihydroxyphenyl)-7-hy...)
Affinity DataIC50:  0.960nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate incubated for 10 mins by spectrophotometer assayMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetEstrogen receptor(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50208612((-)-kurarinone | (2S)-2-(2,4-dihydroxyphenyl)-7-hy...)
Affinity DataEC50:  4.60E+3nMAssay Description:Estrogenic activity at human estrogen receptor expressing Saccharomyces cerevisiae carrying estrogen responsive sequence contatining plasmid assessed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50208612((-)-kurarinone | (2S)-2-(2,4-dihydroxyphenyl)-7-hy...)
Affinity DataEC50:  1.66E+3nMAssay Description:Estrogenic activity at estrogen receptor in human Ishikawa Var-1 cells assessed as stimulation of alkaline phosphatase activity measured by metabolis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDiacylglycerol O-acyltransferase 1(Rat)
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50208612((-)-kurarinone | (2S)-2-(2,4-dihydroxyphenyl)-7-hy...)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibition of DGAT in rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50208612((-)-kurarinone | (2S)-2-(2,4-dihydroxyphenyl)-7-hy...)
Affinity DataIC50:  600nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed