BDBM9426 CHEMBL258928::Heterodimeric Tacrine-Based Inhibitor 5g::N-(8-aminooctyl)-1,2,3,4-tetrahydroacridin-9-amine dihydrochloride::N-9-(1,2,3,4-Tetrahydroacridinyl)-1,8-diamino-octane Bis-hydrochloride

SMILES NCCCCCCCCNc1c2CCCCc2nc2ccccc12

InChI Key InChIKey=LFBAUYQQFKFFCF-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 9426   

TargetAcetylcholinesterase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM9426(CHEMBL258928 | Heterodimeric Tacrine-Based Inhibit...)
Affinity DataIC50:  89.4nMpH: 7.4 T: 37°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarboxylic ester hydrolase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM9426(CHEMBL258928 | Heterodimeric Tacrine-Based Inhibit...)
Affinity DataIC50:  202nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholinesterase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM9426(CHEMBL258928 | Heterodimeric Tacrine-Based Inhibit...)
Affinity DataIC50:  89nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarboxylic ester hydrolase(Horse)
Friedrich-Schiller-Universit£T Jena

Curated by ChEMBL
LigandPNGBDBM9426(CHEMBL258928 | Heterodimeric Tacrine-Based Inhibit...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of equine BChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholinesterase(Electric eel)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM9426(CHEMBL258928 | Heterodimeric Tacrine-Based Inhibit...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of eel AChE using acetylthiocholine iodide as substrate after 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholinesterase(Rat)
Hong Kong University of Science and Technology

LigandPNGBDBM9426(CHEMBL258928 | Heterodimeric Tacrine-Based Inhibit...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rat AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholinesterase(Electric eel)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM9426(CHEMBL258928 | Heterodimeric Tacrine-Based Inhibit...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of electric eel AchE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCholinesterase(Horse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM9426(CHEMBL258928 | Heterodimeric Tacrine-Based Inhibit...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate after 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed