BDBM50241029 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol::CHEMBL383322::R 848::R-848::Resiquimod::US10457681, Compound Resiquimod::US10487084, Compound Resiquimod::US10508115, Compound Resiquimod::US10919895, Resiquimod::US10981914, Compound Resiquimod::US9334268, resiquimod
SMILES CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
InChI Key InChIKey=BXNMTOQRYBFHNZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50241029
Affinity DataEC50: 9.60E+3nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells, respectively, (Invivogen, San Diego, Calif., USA) transfected with a SEAP repo...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 363nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as activation of NFkappaB incubated for 18 to 24 hrs by SEAP reporter gene based as...More data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 260nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6.40E+3nMAssay Description:Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40E+3nMAssay Description:Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...More data for this Ligand-Target Pair
Affinity DataEC50: 6.13E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.34E+3nMAssay Description:Agonist activity at human TLR7 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 420nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) r...More data for this Ligand-Target Pair
Affinity DataEC50: 420nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) r...More data for this Ligand-Target Pair
Affinity DataEC50: 420nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Affinity DataEC50: 4.50E+3nMAssay Description:Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+3nMAssay Description:Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.00E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP r...More data for this Ligand-Target Pair
Affinity DataEC50: 250nMAssay Description:Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP r...More data for this Ligand-Target Pair
Affinity DataEC50: 420nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Affinity DataEC50: 5.87E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 750nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 330nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+3nMAssay Description:Agonist activity in TLR8 (unknown origin) expressed in HEK293 cells assessed as induction of NF-kappa activationMore data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+3nMAssay Description:Activation of TLR7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 4.50E+3nMAssay Description:Activation of TLR8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 1.26E+3nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of IN-12 stimulationMore data for this Ligand-Target Pair
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Affinity DataEC50: 480nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 to 16 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 75nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells incubated for 6 to 16 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+3nMAssay Description:Agonist activity at human TLR7 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 4.50E+3nMAssay Description:Agonist activity at human TLR8 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 67nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells assessed as activation of NFkappaB incubated for 18 to 24 hrs by SEAP reporter gene based as...More data for this Ligand-Target Pair
Affinity DataEC50: 760nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells, respectively, (Invivogen, San Diego, Calif., USA) transfected with a SEAP repo...More data for this Ligand-Target Pair