BDBM50252149 (2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide::(S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-2-(hydroxymethyl)-N-methyl-2-phenyl-2H-pyrrole-1(5H)-carboxamide::CHEMBL481931::MK-0731

SMILES CN([C@H]1CCN(C)C[C@H]1F)C(=O)N1CC(=C[C@@]1(CO)c1ccccc1)c1cc(F)ccc1F

InChI Key InChIKey=MYBGWENAVMIGMM-GIFXNVAJSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50252149   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50:  2.05E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCentromere-associated protein E(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human CENP-EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF23(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human MKLP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF3A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human Kif3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF2C(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human MCAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-1 heavy chain(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human uKHCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin heavy chain isoform 5A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human nKHCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human Kif14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF1B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50252149((2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of cloned human Kif1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed