BDBM50269559 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one::CHEMBL463145::Norartocarpetin, 5::norartocarpetin

SMILES Oc1ccc(c(O)c1)-c1cc(=O)c2c(O)cc(O)cc2o1

InChI Key InChIKey=ZSYPIPFQOQGYHH-UHFFFAOYSA-N

Data  2 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50269559   

TargetPolyphenol oxidase 2(White button mushroom)
Gyeongsang National University

LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKi:  0.610nM ΔG°:  -12.8kcal/moleT: 30°CAssay Description:Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-secretase 1(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKi:  8.26E+4nMAssay Description:Noncompetitive inhibition of human recombinant BACE-1 by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-secretase 1(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  6.06E+4nMAssay Description:Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPancreatic triacylglycerol lipase(Pig)
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: >7.00E+4nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate assessed as formation of p-nitrophenol preincubated for 15 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosinase(Human)
Hiroshima University

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  23nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-dihydroxyphenylalanine as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 22(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  3.03E+4nMAssay Description:Inhibition of LYP (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpB using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 12(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  2.09E+4nMAssay Description:Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  5.18E+3nMAssay Description:Inhibition of human PTP1B using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every minute fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpA using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis PtpB using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyphenol oxidase 2(White button mushroom)
Gyeongsang National University

LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of mushroom tyrosinase assessed as reduction in diphenolase activity using L-DOPA substrate pre-incubated for 20 mins at 30 degCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyphenol oxidase 2(White button mushroom)
Gyeongsang National University

LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  1.20E+3nMT: 30°CAssay Description:Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyphenol oxidase 2(White button mushroom)
Gyeongsang National University

LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: >3.00E+5nMT: 30°CAssay Description:Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed