BDBM50294011 (E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-(3-(4-methyl-1-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide::(E)-3-(2-(6-(cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-phenyl)benzamide::3-(2-(6-(cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide::3-{(E)-2-[6-(cyclopropylamino)-9H-purin-9-yl]ethenyl}-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide::AP-24163::AP24163::CHEMBL539433

SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(\C=C\n3cnc4c(NC5CC5)ncnc34)c2)cc(c1)C(F)(F)F

InChI Key InChIKey=XQBYDVRVYRYLCH-BQYQJAHWSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50294011   

TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

LigandPNGBDBM50294011((E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl...)
Affinity DataIC50:  25nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1 [T315I](Human)
Ariad Pharmaceuticals

LigandPNGBDBM50294011((E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl...)
Affinity DataIC50:  478nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

LigandPNGBDBM50294011((E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of wild type human ABL after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50294011((E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

LigandPNGBDBM50294011((E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of wild type human Abl kinase by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50294011((E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl...)
Affinity DataIC50:  7.60nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed