BDBM50296977 2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetic acid::CHEMBL560993

SMILES Cc1c(Cc2ccc3ccccc3n2)c2cc(F)ccc2n1CC(O)=O

InChI Key InChIKey=FATGTHLOZSXOBC-UHFFFAOYSA-N

Data  1 KI  14 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50296977   

TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataKi:  13nMAssay Description:Antagonistic activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced calcium mobilization after 60 mins by Fluo-3 based fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Human)
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  7.30E+3nMAssay Description:Displacement of [3H]PGD2 from prostaglandin D1 receptor in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Human)
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50: >1.00E+5nMAssay Description:Displacement of [3H]SQ-29548 from thromboxane receptor in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstacyclin receptor(Human)
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  5.79E+4nMAssay Description:Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Human)
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Human)
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Human)
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at CRTH2 expressed in Th2 cells assessed as inhibition of PGD2-induced antiapoptotic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at CRTH2 expressed in Th2 cells assessed as inhibition of PGD2-induced IL13 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at CRTH2 expressed in Th2 cells assessed as inhibition of PGD2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataEC50:  24nMAssay Description:Antagonist activity at CRTH2 in human eosinophils assessed as inhibition of PGD2-induced shape changeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  550nMAssay Description:Inhibition of rat aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  100nMAssay Description:Inhibition of CRTH2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  44nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptor in presence of human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Human)
Oxagen

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed