BDBM50299546 3-{3-Cyano-4-[((2R)-3-{[1,1-dimethyl-2-(2-naphthalenyl)ethyl]-amino}-2-hydroxypropyl)oxy]phenyl}propanoic Acid::CHEMBL570593

SMILES CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1ccc(CCC(O)=O)cc1C#N

InChI Key InChIKey=BKMZXLKUUMOTKA-XMMPIXPASA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50299546   

TargetBeta-2 adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50299546(3-{3-Cyano-4-[((2R)-3-{[1,1-dimethyl-2-(2-naphthal...)
Affinity DataIC50: >30nMAssay Description:Inhibition of beta2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetExtracellular calcium-sensing receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50299546(3-{3-Cyano-4-[((2R)-3-{[1,1-dimethyl-2-(2-naphthal...)
Affinity DataIC50:  0.0220nMAssay Description:Displacement of [3H](2-(2-hydroxyphenyl)-6-methyl-5-(2-methylpropyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone) from human calcium receptor expressed in h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50299546(3-{3-Cyano-4-[((2R)-3-{[1,1-dimethyl-2-(2-naphthal...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent dopamine transporter(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50299546(3-{3-Cyano-4-[((2R)-3-{[1,1-dimethyl-2-(2-naphthal...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50299546(3-{3-Cyano-4-[((2R)-3-{[1,1-dimethyl-2-(2-naphthal...)
Affinity DataIC50: >50nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent serotonin transporter(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50299546(3-{3-Cyano-4-[((2R)-3-{[1,1-dimethyl-2-(2-naphthal...)
Affinity DataIC50:  23nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetExtracellular calcium-sensing receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50299546(3-{3-Cyano-4-[((2R)-3-{[1,1-dimethyl-2-(2-naphthal...)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at human calcium receptor expressed in HEK293 4.0-7 cells assessed as inhibition of intracellular calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50299546(3-{3-Cyano-4-[((2R)-3-{[1,1-dimethyl-2-(2-naphthal...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed