BDBM50303755 (R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one::CHEMBL585120

SMILES COc1ccc(cc1C)[C@]1(N=C(N)N(C)C1=O)C12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=HZIOSWLCMNAEBB-QVLKYBFXSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50303755   

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303755((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303755((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataIC50:  1.31E+4nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-secretase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303755((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataIC50:  7.36E+4nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-secretase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303755((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-3-methyl...)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed