BDBM50312057 CHEMBL1087397::N-(3-(3-(4-((dimethylamino)methyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide::N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide

SMILES CN(C)Cc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1

InChI Key InChIKey=AIWJVLQNYNCDSL-UHFFFAOYSA-N

Data  15 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50312057   

TargetProtein kinase C alpha type(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50:  25nMAssay Description:Inhibition of cRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50:  216nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of IKKbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of MKK6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50312057(CHEMBL1087397 | N-(3-(3-(4-((dimethylamino)methyl)...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair