BDBM50318482 (-)-menthol::CHEMBL470670::MENTHOL::US11406649, Code Menthol::l-menthol

SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O

InChI Key InChIKey=NOOLISFMXDJSKH-KXUCPTDWSA-N

Data  1 IC50  1 Kd  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50318482   

LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataEC50:  7.50E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataEC50:  2.84E+4nMAssay Description:Activation of TRPA1 channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataEC50:  5.60E+4nMAssay Description:Antagonist activity at mouse TRPA1 channel expressed in CHO cells assessed as blockade of agonist-induced whole cell conductance by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataIC50:  9.20E+4nMAssay Description:Displacement of [3H]menthol from human TRPM8 expressed in HEK293 cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataEC50:  6.00E+4nMAssay Description:Agonist activity at TRPM8 (unknown origin) by fluorometric imaging plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataEC50:  2.90E+4nMAssay Description:Activity at human TRPM8 expressed in HEK293 cells assessed as compound concentration causing leftward shift of voltage for half maximal activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataEC50:  9.60E+4nMAssay Description:Agonist activity at recombinant human TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for 5 mins by Fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataEC50:  1.01E+4nMAssay Description:Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataEC50:  3.80E+3nMAssay Description:In the first set of data, the potency and in vitro effects of test compounds were evaluated on cloned hTRPM8 channel (encoded by the human TRPM8 gene...More data for this Ligand-Target Pair
In DepthDetails US Patent
DrugBank

LigandPNGBDBM50318482((-)-menthol | CHEMBL470670 | MENTHOL | US11406649,...)
Affinity DataKd:  1.44E+4nMAssay Description:Binding affinity to human TRPM8 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank