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BDBM50318482 (-)-menthol::CHEMBL470670::MENTHOL::l-menthol

SMILES: CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O

InChI Key: InChIKey=NOOLISFMXDJSKH-KXUCPTDWSA-N

Data: 1 IC50  1 Kd  5 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50318482   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50318482
PNG
((-)-menthol | CHEMBL470670 | MENTHOL | l-menthol)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
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Article
PubMed
n/an/an/an/a 7.50E+4n/an/an/an/a



University of Salerno

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...


J Med Chem 59: 2179-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01914
BindingDB Entry DOI: 10.7270/Q2B85B1Z
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50318482
PNG
((-)-menthol | CHEMBL470670 | MENTHOL | l-menthol)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay


Bioorg Med Chem Lett 23: 6118-22 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50318482
PNG
((-)-menthol | CHEMBL470670 | MENTHOL | l-menthol)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
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KEGG

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n/an/an/an/a 2.84E+4n/an/an/an/a



Ferrara University

Curated by ChEMBL


Assay Description
Activation of TRPA1 channel


J Med Chem 53: 5085-107 (2010)


Article DOI: 10.1021/jm100062h
BindingDB Entry DOI: 10.7270/Q2416Z02
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50318482
PNG
((-)-menthol | CHEMBL470670 | MENTHOL | l-menthol)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
KEGG

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n/an/an/an/a 2.90E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activity at human TRPM8 expressed in HEK293 cells assessed as compound concentration causing leftward shift of voltage for half maximal activation


Nat Chem Biol 3: 174-82 (2007)


Article DOI: 10.1038/nchembio862
BindingDB Entry DOI: 10.7270/Q2057G4K
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50318482
PNG
((-)-menthol | CHEMBL470670 | MENTHOL | l-menthol)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
KEGG

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Article
PubMed
n/an/a 9.20E+4n/an/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Displacement of [3H]menthol from human TRPM8 expressed in HEK293 cell membranes by scintillation counting


Nat Chem Biol 3: 174-82 (2007)


Article DOI: 10.1038/nchembio862
BindingDB Entry DOI: 10.7270/Q2057G4K
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50318482
PNG
((-)-menthol | CHEMBL470670 | MENTHOL | l-menthol)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
KEGG

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Article
PubMed
n/an/an/a 1.44E+4n/an/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Binding affinity to human TRPM8 expressed in HEK293 cell membranes


Nat Chem Biol 3: 174-82 (2007)


Article DOI: 10.1038/nchembio862
BindingDB Entry DOI: 10.7270/Q2057G4K
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Mus musculus)
BDBM50318482
PNG
((-)-menthol | CHEMBL470670 | MENTHOL | l-menthol)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
Reactome pathway
KEGG

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CHEMBL
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PC sid
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Article
PubMed
n/an/an/an/a 5.60E+4n/an/an/an/a



Ferrara University

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPA1 channel expressed in CHO cells assessed as blockade of agonist-induced whole cell conductance by electrophysiology


J Med Chem 53: 5085-107 (2010)


Article DOI: 10.1021/jm100062h
BindingDB Entry DOI: 10.7270/Q2416Z02
More data for this
Ligand-Target Pair