BDBM50323635 6-(4-chlorophenyl)-N-(4-(4-methylpiperazin-1-yl)phenyl)quinolin-4-amine::CHEMBL1208951

SMILES CN1CCN(CC1)c1ccc(Nc2ccnc3ccc(cc23)-c2ccc(Cl)cc2)cc1

InChI Key InChIKey=CQERPSZQVAXWHF-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50323635   

TargetMAP kinase-activated protein kinase 2(Human)
Astrazeneca R & D Lund

Curated by ChEMBL
LigandPNGBDBM50323635(6-(4-chlorophenyl)-N-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataKi:  96nMAssay Description:Competitive inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Astrazeneca R & D Lund

Curated by ChEMBL
LigandPNGBDBM50323635(6-(4-chlorophenyl)-N-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataKi:  310nMAssay Description:Uncompetitive inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Astrazeneca R & D Lund

Curated by ChEMBL
LigandPNGBDBM50323635(6-(4-chlorophenyl)-N-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataKi:  320nMAssay Description:Mixed inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Astrazeneca R & D Lund

Curated by ChEMBL
LigandPNGBDBM50323635(6-(4-chlorophenyl)-N-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataKi:  480nMAssay Description:Noncompetitive inhibition of MK2 ATP-binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Astrazeneca R & D Lund

Curated by ChEMBL
LigandPNGBDBM50323635(6-(4-chlorophenyl)-N-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50:  600nMAssay Description:Inhibition of MK2 assessed as inhibition of [33P]ATP incorporation in to substrate after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed