BindingDB BDBM50331277 3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine::CHEMBL1288582

BDBM50331277 3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine::CHEMBL1288582

SMILES COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12

InChI Key InChIKey=PRASIGARSOSUQT-UHFFFAOYSA-N

Data 32 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50331277

Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 5.38E+3nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Tyrosine-protein kinase ITK/TSK(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 60nMAssay Description:Inhibition of recombinant GST-tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Aurora kinase B(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 270nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Death-associated protein kinase 1(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: >3.00E+4nMAssay Description:Inhibition of DAPK1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cyclin-dependent kinase 5 activator 1(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 7.41E+3nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 5.23E+3nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 5.94E+3nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Tyrosine-protein kinase ITK/TSK(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 60nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cyclin-dependent kinase 2(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 4.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Tyrosine-protein kinase ABL1(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 7.68E+3nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Aurora kinase A(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 190nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase B-raf(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: >3.00E+4nMAssay Description:Inhibition of B-rafMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase MRCK beta(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: >3.00E+4nMAssay Description:Inhibition of CDC42 BpBMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Casein kinase II subunit alpha(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: >3.00E+4nMAssay Description:Inhibition of CK2-alpha1More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Focal adhesion kinase 1(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 5.49E+3nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Receptor-type tyrosine-protein kinase FLT3(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 60nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Inhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: >3.00E+4nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual specificity mitogen-activated protein kinase kinase 1(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 2.45E+3nMAssay Description:Inhibition of MEK-1More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase Nek2(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 3.22E+3nMAssay Description:Inhibition of NEK-2More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Mitogen-activated protein kinase 14(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: >3.00E+4nMAssay Description:Inhibition of p38-alphaMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase PAK 2(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: >3.00E+4nMAssay Description:Inhibition of PAK2More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Lymphokine-activated killer T-cell-originated protein kinase(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: >3.00E+4nMAssay Description:Inhibition of PBKMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Platelet-derived growth factor receptor beta(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 3.20E+3nMAssay Description:Inhibition of PDGFR-betaMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein kinase C beta type(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: >3.00E+4nMAssay Description:Inhibition of PKC-beta1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Protein kinase C theta type(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 2.24E+4nMAssay Description:Inhibition of PKC-thetaMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase PLK1(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: >3.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Serine/threonine-protein kinase PLK4(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 3.82E+3nMAssay Description:Inhibition of SAKMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Proto-oncogene tyrosine-protein kinase Src(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 1.31E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual specificity protein kinase TTK(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 8.75E+3nMAssay Description:Inhibition of TTKMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Vascular endothelial growth factor receptor 2(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 310nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Wee1-like protein kinase(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 5.72E+3nMAssay Description:Inhibition of WEE1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Nycomed

Curated by ChEMBL

BDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)

IC50: 1.45E+3nMAssay Description:Inhibition of CDK4/Cyclin D1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Filter my 32 hits

Targets 31▿
- Tyrosine-protein kinase ITK/TSK 2
- Death-associated protein kinase 1 1
- Dual specificity protein kinase TTK 1
- Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 1
- Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 1
- Mitogen-activated protein kinase 14 1
- Serine/threonine-protein kinase B-raf 1
- Aurora kinase B 1
- Vascular endothelial growth factor receptor 2 1
- Casein kinase II subunit alpha 1
- Aurora kinase A 1
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 1
- Cyclin-dependent kinase 5 activator 1 1
- Serine/threonine-protein kinase PLK1 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Wee1-like protein kinase 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Serine/threonine-protein kinase Nek2 1
- Serine/threonine-protein kinase PLK4 1
- Tyrosine-protein kinase ABL1 1
- Protein kinase C beta type 1
- Protein kinase C theta type 1
- Focal adhesion kinase 1 1
- Serine/threonine-protein kinase PAK 2 1
- Cyclin-dependent kinase 2 1
- Lymphokine-activated killer T-cell-originated protein kinase 1
- Serine/threonine-protein kinase Chk1 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Platelet-derived growth factor receptor beta 1
- Serine/threonine-protein kinase MRCK beta 1
- Proto-oncogene tyrosine-protein kinase Src 1
Publications 2▿
- Bioorg Med Chem Lett 20: 6998-7003 (2010) 31
- Bioorg Med Chem Lett 21: 1852-6 (2011) 1
Institutions 1▿
- Nycomed 32
Affinity: 60 to 3.0E+4 nM▿
- IC50 32
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0