BDBM50338873 CHEMBL1684800::N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-2-methylbenzamide

SMILES COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)ccc3C)c2N)cc1

InChI Key InChIKey=ZJDFSKSBQBPOSK-UHFFFAOYSA-N

Data  20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50338873   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  2.13nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
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TargetMitogen-activated protein kinase 10(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:inhibition of JNK3More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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TargetGlycogen synthase kinase-3 beta(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  2.73nMAssay Description:inhibition of GSK3-betaMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  2.87nMAssay Description:inhibition of RAF1More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.20nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
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TargetFocal adhesion kinase 1(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  4.13nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  4.79nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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TargetVascular endothelial growth factor receptor 2(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  9.42nMAssay Description:inhibition of KDRMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  18.2nMAssay Description:inhibition of MEK1More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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TargetFibroblast growth factor receptor 3(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  21.5nMAssay Description:inhibition of FGFR3More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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TargetInsulin-like growth factor 1 receptor(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  51.6nMAssay Description:inhibition of IGF-1RMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetEpidermal growth factor receptor(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  101nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  107nMAssay Description:Inhibition of C-Raf assessed as [33P]gamma-ATP incorporation into substrate after 40 mins by scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetSerine/threonine-protein kinase PLK1(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  167nMAssay Description:inhibition of PLK1More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetHepatocyte growth factor receptor(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  194nMAssay Description:Inhibition of c-METMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetMacrophage-stimulating protein receptor(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  277nMAssay Description:inhibition of RONMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetMitogen-activated protein kinase 8(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  1.59E+3nMAssay Description:inhibition of JNK1a1 at 10 uMMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetSerine/threonine-protein kinase mTOR(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.02E+3nMAssay Description:inhibition of mTORMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetMitogen-activated protein kinase 1(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetALK tyrosine kinase receptor(Human)
Hanyang University

Curated by ChEMBL

LigandBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  2.71nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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