BDBM50340727 2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyrimidine::CHEMBL1762570::US8552005, 1.1(13)

SMILES Cc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1

InChI Key InChIKey=SIJFRULREICUCH-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50340727   

Target5-hydroxytryptamine receptor 6(Human)
Avincuro Pharmaceuticals

US Patent
LigandPNGBDBM50340727(2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyr...)
Affinity DataKi:  68.4nM IC50:  147nMAssay Description:Radioligand binding assay using 5-HT6 receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent

Target5-hydroxytryptamine receptor 6(Human)
Avincuro Pharmaceuticals

US Patent
LigandPNGBDBM50340727(2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyr...)
Affinity DataKi:  68.4nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Human)
Avincuro Pharmaceuticals

US Patent
LigandPNGBDBM50340727(2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyr...)
Affinity DataKi:  88.8nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed