BDBM50340918 4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoline::CHEMBL1277620::N-(4-bromo-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine

SMILES COc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1OC

InChI Key InChIKey=VHFBRSZCMAZULY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50340918   

TargetVascular endothelial growth factor receptor 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  460nMAssay Description:Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of KDR (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based lumine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed