BDBM50343528 3-(9-(3-bromo-4-(4-chlorobenzyloxy)phenyl)-3,3,6,6-tetramethyl-1,8-dioxo-1,2,3,4,5,6,7,8-octahydroacridin-10(9H)-yl)propanoic acid::CHEMBL1774307

SMILES CC1(C)CC(=O)C2=C(C1)N(CCC(O)=O)C1=C(C2c2ccc(OCc3ccc(Cl)cc3)c(Br)c2)C(=O)CC(C)(C)C1

InChI Key InChIKey=LDEXSAJYKKIZII-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343528   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343528(3-(9-(3-bromo-4-(4-chlorobenzyloxy)phenyl)-3,3,6,6...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343528(3-(9-(3-bromo-4-(4-chlorobenzyloxy)phenyl)-3,3,6,6...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343528(3-(9-(3-bromo-4-(4-chlorobenzyloxy)phenyl)-3,3,6,6...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed