BDBM50369077 CHEMBL4168496

SMILES CCS(=O)(=O)c1ccc(cc1)C(NC(C)=O)C(=O)Nc1cc(cs1)-c1cc(cc(F)c1OC)C#N

InChI Key InChIKey=YOJMBDUWFJVSKK-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50369077   

TargetNuclear receptor ROR-alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)
Affinity DataIC50:  1.90E+4nMAssay Description:Inverse agonist activity at His6-tcs-human RORalpha LBD assessed as inhibition of biotinylated PGC1alpha (130 to 154 residues) peptide recruitment in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)
Affinity DataIC50:  57nMAssay Description:Inverse agonist activity at RORgammat in human TH17 cells assessed as inhibition of IL17 release incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)
Affinity DataIC50: >3.30E+4nMAssay Description:Agonist activity at His6-tcs-human RORalpha LBD assessed as stimulation of biotinylated PGC1alpha (130 to 154 residues) peptide recruitment incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)
Affinity DataIC50:  63nMAssay Description:Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator measu...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)
Affinity DataIC50:  63nMAssay Description:Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to 518 residues) assessed as inhibition of biotinylated SRC-1 peptide NC...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)
Affinity DataIC50:  63nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)
Affinity DataIC50:  3.16E+4nMAssay Description:Agonist activity at human His6-tcs-RORalpha LBD assessed as PGC1alpha peptide (130 to 154 residues) recruitment incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-beta(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]ATRA from 6H-AVI-GST-TEV-human RORbeta (T221 to K470 residues) pre-incubated for 30 mins before [3H]ATRA addition and measurted a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed