BDBM50375654 CHEMBL99203::US11633415, Compound 5-iodotubercidin
SMILES Nc1ncnc2n(cc(I)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
InChI Key InChIKey=WHSIXKUPQCKWBY-IOSLPCCCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50375654
Affinity DataKi: 9.30nMAssay Description:Inhibition of Sprague-Dawley rat brain cytosolic Adk using [2-3H]adenosine incubated for 15 mins by scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Reversible inhibition of recombinant human Adk-short expressed in Escherichia coli BL21[DE3] assessed as [3H]AMP formation preincubated for 15 mins f...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of rat brain ADK expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Inhibition of recombinant human Adk using [U-14C]adenosine by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of adhenosine kinaseChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of purified human adenosine kinase using varying levels of [3H]Ado as substrate in presence of adenosine deaminase inhibitor deoxycoformyc...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of human placental adenosine kinaseMore data for this Ligand-Target Pair
TargetAdenosine kinase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Texas A&M University
Curated by ChEMBL
Texas A&M University
Curated by ChEMBL
Affinity DataKi: 210nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Ra ATCC 25177 adenosine kinase using varying levels of [3H]Ado as substrate in presence of adenosine deam...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 530nMAssay Description:Inhibition of ERK2Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of human adenosine kinase assessed as reduction in conversion of adenosine to AMPMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Affinity DataIC50: 71nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 287nMAssay Description:In order to identify inhibitors of CSNK1A1, the CSNK1A1 knockdown signatures in CMap were compared to all CMap compound signatures, and resultant com...More data for this Ligand-Target Pair
Affinity DataIC50: 820nMAssay Description:Inhibition of human adenosine kinase assessed as effect on reduced nicotinamide-adenine dinculeotide appearance using inosine as substrate in presenc...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of DOT1L (unknown origin) using chicken nucleosome as substrate in presence of [3H]SAM incubated for 1 hr by TopCount methodMore data for this Ligand-Target Pair
TargetAdenosine kinase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Texas A&M University
Curated by ChEMBL
Texas A&M University
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of wild-type N-terminal TEV cleavage site-fused/His-tagged Mycobacterium tuberculosis H37Rv adenosine kinase expressed in Escherichia coli...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+7nMAssay Description:Inhibition of adenosine kinase (unknown origin)More data for this Ligand-Target Pair
TargetEquilibrative nucleoside transporter 1(Human)
University of Tennessee Health Science Center
Curated by ChEMBL
University of Tennessee Health Science Center
Curated by ChEMBL
Affinity DataIC50: 2.29E+5nMAssay Description:Binding affinity to ENT1 transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 25.7nMAssay Description:Concentration required for 50% inhibition of the adenosine kinase (AK) activity.More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 1.82E+4nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Genomics Institute of The Novartis Research Foundation (Gnf)
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of DYRK1A (unknown origin) in presence of ATP at 15 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of ERK2 (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Competitive inhibition of recombinant human DOT1L using adenosine/deazaadenosine as substrate and SAM cofactorMore data for this Ligand-Target Pair