BDBM50378657 CHEMBL1230607

SMILES CC(C)CC(=O)Nc1[nH]nc2c1CN(C(=O)C1CCN(C)CC1)C2(C)C

InChI Key InChIKey=HUXYBQXJVXOMKX-UHFFFAOYSA-N

Data  42 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 50378657   

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK7/cyclin H by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  60nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  8nMAssay Description:Inhibition of human CDK2/cyclin A expressed in Escherichia coli BL21 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2/cyclin E by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora B by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CHK1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  138nMAssay Description:Inhibition of CDK9/cyclin T1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  62nMAssay Description:Inhibition of CDK4/cyclin D1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  79nMAssay Description:Inhibition of GSK3-beta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-ABL by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR3 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RET by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKAalpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PAK4 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek6(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of NEK6 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCK by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of cKit by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK2 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGF1R by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FLT3 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDC7 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora A by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALK by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5(Human)
Mizoram University

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed