BDBM8353 6-aryl-pyrazolo[3,4-b]pyridine analogue 17::CHEMBL259270::N-{5-bromo-6-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}cyclopropanecarboxamide::pyrazolo[3,4-b]pyridine analogue 3

SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccccc1

InChI Key InChIKey=RPSIDICSSBFGPU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8353   

TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8353(6-aryl-pyrazolo[3,4-b]pyridine analogue 17 | CHEMB...)
Affinity DataIC50:  75nMpH: 7.0 T: 22°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8353(6-aryl-pyrazolo[3,4-b]pyridine analogue 17 | CHEMB...)
Affinity DataIC50:  75nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM8353(6-aryl-pyrazolo[3,4-b]pyridine analogue 17 | CHEMB...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8353(6-aryl-pyrazolo[3,4-b]pyridine analogue 17 | CHEMB...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed