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Found 1038 with Last Name = 'zhao' and Initial = 'r'
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109021((R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...)
Affinity DataKi:  0.0700nMAssay Description:Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  0.140nMAssay Description:Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109020(8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-chrom...)
Affinity DataKi:  0.140nMAssay Description:Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061669((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...)
Affinity DataKi:  0.200nMAssay Description:Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]Spiprone from human dopamine D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109021((R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...)
Affinity DataKi:  0.400nMAssay Description:Affinity for the Human Dopamine receptor D3 was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  0.620nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109020(8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-chrom...)
Affinity DataKi:  1nMAssay Description:Affinity for the Human Dopamine receptor D3 was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM82247(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataKi:  1.24nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077569(Benzyl-[(R)-1-(2,3,4,7-tetrahydro-pyrano[2,3-e]ind...)
Affinity DataKi:  1.90nMAssay Description:Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...)
Affinity DataKi:  2.24nMAssay Description:Displacement of [3H]Ketanserin from human 5HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061669((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...)
Affinity DataKi:  2.40nMAssay Description:Affinity for the Human Dopamine receptor D3 was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  2.40nMAssay Description:Affinity for the Human Dopamine receptor D3 was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50387561(CHEMBL2057455 | US9359372, DC037079)
Affinity DataKi:  2.53nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109021((R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...)
Affinity DataKi:  3nMAssay Description:Affinity for the Dopamine receptor D2S was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50235306(CHEMBL4084621)
Affinity DataKi:  3.30nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061669((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...)
Affinity DataKi:  3.30nMAssay Description:Affinity of compound for Dopamine receptor D2 in rat striatal membrane determined for antagonist state (low affinity state, D2 Low) with [3H]spiperon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  4nMAssay Description:Binding affinity against human Cannabinoid receptor 2 expressed in CHO cells by using WIN 55,2122Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109021((R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...)
Affinity DataKi:  4.80nMAssay Description:Affinity of compound for Dopamine receptor D2 in rat striatal membrane determined for antagonist state (low affinity state, D2 Low) with [3H]spiperon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  4.80nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109020(8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-chrom...)
Affinity DataKi:  5nMAssay Description:Affinity for the Dopamine receptor D2S was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50451435(CHEMBL2112289)
Affinity DataKi:  5nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109024((S)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...)
Affinity DataKi:  5.5nMAssay Description:Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109019(Benzyl-(2-trifluoromethyl-3,6,7,8-tetrahydro-chrom...)
Affinity DataKi:  5.80nMAssay Description:Affinity of compound for D2 receptor in rat striatal membrane determined for agonist state (high affinity state, D2 High) [3H]quinpirole as radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  5.90nMAssay Description:Affinity of compound for Dopamine receptor D2 in rat striatal membrane determined for antagonist state (low affinity state, D2 Low) with [3H]spiperon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50378584(STEPHOLIDINE)
Affinity DataKi:  6.23nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109021((R)-8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-c...)
Affinity DataKi:  7nMAssay Description:Affinity for the Human Dopamine receptor D4 was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109020(8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-chrom...)
Affinity DataKi:  7nMAssay Description:Affinity of compound for Dopamine receptor D2 in rat striatal membrane determined for antagonist state (low affinity state, D2 Low) with [3H]spiperon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50387564(CHEMBL2057445)
Affinity DataKi:  7.97nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50116857(7-Methoxy-2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-i...)
Affinity DataKi:  8nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50116851((S)-2-{[7-Methoxy-2-methyl-1-(2-morpholin-4-yl-eth...)
Affinity DataKi:  8nMAssay Description:Binding affinity against human Cannabinoid receptor 2 expressed in CHO cells by using WIN 55,2122Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50235306(CHEMBL4084621)
Affinity DataKi:  8.10nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50077581((R)-2-(Benzylamino-methyl)-3,4,7,9-tetrahydro-2H-p...)
Affinity DataKi:  9.30nMAssay Description:Affinity for the Dopamine receptor D2S was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM50385299(CHEMBL2035464 | US8592468, EbSe16)
Affinity DataKi:  10nM IC50:  2.25E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50061669((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...)
Affinity DataKi:  10nMAssay Description:Affinity for the Dopamine receptor D2S was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Wyeth-Ayerst Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109020(8-(Benzylamino-methyl)-3,6,7,8-tetrahydro-1H-chrom...)
Affinity DataKi:  10nMAssay Description:Affinity for the Human Dopamine receptor D4 was determined using membranes from CHO cells labeled with [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50116855((S)-2-{[7-Methoxy-2-methyl-1-(2-morpholin-4-yl-eth...)
Affinity DataKi:  12nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50116849(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indole-3-c...)
Affinity DataKi:  12nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50451436(CHEMBL2112287)
Affinity DataKi:  13nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50387558(CHEMBL2057456)
Affinity DataKi:  17.3nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50451431(CHEMBL2112293)
Affinity DataKi:  18nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50116837((S)-2-{[7-Methoxy-2-methyl-1-(2-morpholin-4-yl-eth...)
Affinity DataKi:  20nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50116859(7-Methoxy-1-(2-morpholin-4-yl-ethyl)-1H-indole-3-c...)
Affinity DataKi:  22nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50387563(CHEMBL2057446)
Affinity DataKi:  23.8nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50116847(7-Methoxy-2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-i...)
Affinity DataKi:  24nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50451434(CHEMBL2112290)
Affinity DataKi:  25nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50387557(CHEMBL2057457 | US9359372, DC037031)
Affinity DataKi:  28.9nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50116860(7-Methoxy-2-methyl-1-(2-morpholin-4-yl-ethyl)-1H-i...)
Affinity DataKi:  30nMAssay Description:Binding affinity against human CB2 receptor expressed in CHO cells by using WIN55,2122 Mesylate [5,73H] as Radioactive tracerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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