BindingDB PrimarySearch

BDBM35228 CHEMBL21731::Dibencycladine::Ludiomil::maprotiline

SMILES: CNCCCC12CCC(c3ccccc13)c1ccccc21

InChI Key: InChIKey=QSLMDECMDJKHMQ-UHFFFAOYSA-N

Data: 12 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 35228
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H1 receptor (Homo sapiens (Human))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Foundation Curated by PDSP K_i Database									Brain Res 304: 1-7 (1984) Article DOI: 10.1016/0006-8993(84)90856-4 BindingDB Entry DOI: 10.7270/Q21N7ZMS
Mayo Foundation Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.67	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johann Wolfgang Goethe Universit£t Curated by ChEMBL					Assay Description Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells				Bioorg Med Chem Lett 19: 538-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.012 BindingDB Entry DOI: 10.7270/Q25H7H6W
Johann Wolfgang Goethe Universit£t Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	11.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Curated by PDSP K_i Database									Eur J Pharmacol 340: 249-58 (1997) Article DOI: 10.1016/s0014-2999(97)01393-9 BindingDB Entry DOI: 10.7270/Q2V69H3D
Mayo Clinic Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	12	-11.2	n/a	n/a	n/a	n/a	n/a	7.4	37
Wyeth Research					Assay Description Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...				Bioorg Med Chem 17: 7802-15 (2009) Article DOI: 10.1016/j.bmc.2009.09.023 BindingDB Entry DOI: 10.7270/Q26Q1VK2
Wyeth Research					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Turku Curated by PDSP K_i Database									Psychopharmacology (Berl) 126: 234-40 (1996) Article DOI: 10.1007/bf02246453 BindingDB Entry DOI: 10.7270/Q2BP0192
University of Turku Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	122	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Turku Curated by PDSP K_i Database									Psychopharmacology (Berl) 126: 234-40 (1996) Article DOI: 10.1007/bf02246453 BindingDB Entry DOI: 10.7270/Q2BP0192
University of Turku Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Turku Curated by PDSP K_i Database									Psychopharmacology (Berl) 126: 234-40 (1996) Article DOI: 10.1007/bf02246453 BindingDB Entry DOI: 10.7270/Q2BP0192
University of Turku Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Curated by PDSP K_i Database									Eur J Pharmacol 340: 249-58 (1997) Article DOI: 10.1016/s0014-2999(97)01393-9 BindingDB Entry DOI: 10.7270/Q2V69H3D
Mayo Clinic Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.19E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wake Forest University Curated by PDSP K_i Database									J Pharmacol Exp Ther 293: 686-96 (2000) BindingDB Entry DOI: 10.7270/Q2H993QF
Wake Forest University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wake Forest University Curated by PDSP K_i Database									J Pharmacol Exp Ther 293: 686-96 (2000) BindingDB Entry DOI: 10.7270/Q2H993QF
Wake Forest University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Curated by PDSP K_i Database									Eur J Pharmacol 340: 249-58 (1997) Article DOI: 10.1016/s0014-2999(97)01393-9 BindingDB Entry DOI: 10.7270/Q2V69H3D
Mayo Clinic Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM35228 (CHEMBL21731 \| Dibencycladine \| Ludiomil \| maprotil...) Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wake Forest University Curated by PDSP K_i Database									J Pharmacol Exp Ther 293: 686-96 (2000) BindingDB Entry DOI: 10.7270/Q2H993QF
Wake Forest University Curated by PDSP K_i Database					More data for this Ligand-Target Pair