BindingDB PrimarySearch

BDBM50240680 1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol::BIPERIDEN::CHEMBL1101::alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropanol::alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol

SMILES: OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1

InChI Key: InChIKey=YSXKPIUOCJLQIE-UHFFFAOYSA-N

Data: 14 KI 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50240680
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Curated by PDSP K_i Database									J Pharmacol Exp Ther 260: 576-80 (1992) BindingDB Entry DOI: 10.7270/Q28P5Z0G
Mayo Clinic Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Walter Reed Army Institute of Research Curated by ChEMBL					Assay Description Displacement of [3H] N-methylscopolamine from human muscarinic M3 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis				Bioorg Med Chem 21: 2651-62 (2013) Article DOI: 10.1016/j.bmc.2013.01.072 BindingDB Entry DOI: 10.7270/Q2X92F6X
Walter Reed Army Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Curated by PDSP K_i Database									J Pharmacol Exp Ther 260: 576-80 (1992) BindingDB Entry DOI: 10.7270/Q28P5Z0G
Mayo Clinic Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Curated by PDSP K_i Database									J Pharmacol Exp Ther 260: 576-80 (1992) BindingDB Entry DOI: 10.7270/Q28P5Z0G
Mayo Clinic Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Curated by PDSP K_i Database									J Pharmacol Exp Ther 260: 576-80 (1992) BindingDB Entry DOI: 10.7270/Q28P5Z0G
Mayo Clinic Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	0.540	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Group Research Ltd. Curated by PDSP K_i Database									Mol Pharmacol 38: 805-15 (1990) BindingDB Entry DOI: 10.7270/Q2H993P0
Glaxo Group Research Ltd. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	10.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Group Research Ltd. Curated by PDSP K_i Database									Mol Pharmacol 38: 805-15 (1990) BindingDB Entry DOI: 10.7270/Q2H993P0
Glaxo Group Research Ltd. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (RAT)	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	1.86	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Group Research Ltd. Curated by PDSP K_i Database									Mol Pharmacol 38: 805-15 (1990) BindingDB Entry DOI: 10.7270/Q2H993P0
Glaxo Group Research Ltd. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor (RABBIT)	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	2.04	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Group Research Ltd. Curated by PDSP K_i Database									Mol Pharmacol 38: 805-15 (1990) BindingDB Entry DOI: 10.7270/Q2H993P0
Glaxo Group Research Ltd. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Chick)	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Group Research Ltd. Curated by PDSP K_i Database									Mol Pharmacol 38: 805-15 (1990) BindingDB Entry DOI: 10.7270/Q2H993P0
Glaxo Group Research Ltd. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Sodium channel protein type 1/2/3 subunit alpha (Homo sapiens (Human))	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...				J Med Chem 28: 381-8 (1985) Article DOI: 10.1021/jm00381a019 BindingDB Entry DOI: 10.7270/Q2Z321T8
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Walter Reed Army Institute of Research Curated by ChEMBL					Assay Description Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis				Bioorg Med Chem 21: 2651-62 (2013) Article DOI: 10.1016/j.bmc.2013.01.072 BindingDB Entry DOI: 10.7270/Q2X92F6X
Walter Reed Army Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Walter Reed Army Institute of Research Curated by ChEMBL					Assay Description Displacement of [3H] N-methylscopolamine from human muscarinic M4 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis				Bioorg Med Chem 21: 2651-62 (2013) Article DOI: 10.1016/j.bmc.2013.01.072 BindingDB Entry DOI: 10.7270/Q2X92F6X
Walter Reed Army Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Walter Reed Army Institute of Research Curated by ChEMBL					Assay Description Displacement of [3H] N-methylscopolamine from human muscarinic M1 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis				Bioorg Med Chem 21: 2651-62 (2013) Article DOI: 10.1016/j.bmc.2013.01.072 BindingDB Entry DOI: 10.7270/Q2X92F6X
Walter Reed Army Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50240680 (1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piper...) Show SMILES OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mayo Clinic Curated by PDSP K_i Database									J Pharmacol Exp Ther 260: 576-80 (1992) BindingDB Entry DOI: 10.7270/Q28P5Z0G
Mayo Clinic Curated by PDSP K_i Database					More data for this Ligand-Target Pair