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Found 3145 with Last Name = 'tew' and Initial = 'd'
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098576(5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ...)
Affinity DataKi:  0.00480nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM194((5R,6R)-1,5-dibenzyl-6-hydroxy-2,4-bis[(4-hydroxy-...)
Affinity DataKi:  0.00500nM ΔG°:  -65.6kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM520(1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition constant of ritonavir towards HIV protease was determinedMore data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17428(1,2,4-Triazole Compound, 86 | N-[5-(benzylsulfanyl...)
Affinity DataKi:  0.0400nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17355(1,2,4-Triazole Compound, 13 | 5-(benzylsulfanyl)-N...)
Affinity DataKi:  0.0400nM ΔG°:  -58.8kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17388(1,2,4-Triazole Compound, 46 | 5-(benzylsulfanyl)-N...)
Affinity DataKi:  0.0500nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM195((5R,6R)-1,5-dibenzyl-2-(cyclopropylmethyl)-6-hydro...)
Affinity DataKi:  0.0620nM ΔG°:  -59.2kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17365(1,2,4-Triazole Compound, 23 | 5-(benzylsulfanyl)-N...)
Affinity DataKi:  0.0700nM ΔG°:  -57.4kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM192((5R,6R)-1,5-dibenzyl-6-hydroxy-2,4-bis[(4-hydroxyp...)
Affinity DataKi:  0.0700nM ΔG°:  -58.9kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17390(1,2,4-Triazole Compound, 48 | 5-{[(2-fluorophenyl)...)
Affinity DataKi:  0.130nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17362(1,2,4-Triazole Compound, 20 | 5-[(3-methylbut-2-en...)
Affinity DataKi:  0.150nM ΔG°:  -55.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17395(1,2,4-Triazole Compound, 53 | N-(4-methoxyphenyl)-...)
Affinity DataKi:  0.160nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM193((5R,6R)-1,5-dibenzyl-6-hydroxy-2,4-bis[(3-methoxyp...)
Affinity DataKi:  0.220nM ΔG°:  -56.0kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM189((5R,6R)-1,5-dibenzyl-6-hydroxy-2,4-bis({[4-(hydrox...)
Affinity DataKi:  0.220nM ΔG°:  -56.0kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17358(1,2,4-Triazole Compound, 16 | 5-{[(2-fluorophenyl)...)
Affinity DataKi:  0.230nM ΔG°:  -54.5kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50365695(CHEMBL1958408)
Affinity DataKi:  0.280nMAssay Description:Inhibition of human Cdc7 using biotin-C6linker-TPSDSLIYDDGLS as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17430(1,2,4-Triazole Compound, 88 | N-(5-{[(2-fluorophen...)
Affinity DataKi:  0.300nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM35048(benzothienopyrimidinone deriv., 20c)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/moleT: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17411(1,2,4-Triazole Compound, 69 | methyl 4-[(5-{[(2-fl...)
Affinity DataKi:  0.410nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17377(1,2,4-Triazole Compound, 35 | 5-(benzylsulfanyl)-N...)
Affinity DataKi:  0.430nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098576(5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ...)
Affinity DataKi:  0.490nMAssay Description:Inhibitory activity of the compound against Human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM190((5R,6R)-2,4-Bis[4-(hydroxymethyl)benzyl]-1-(3-fura...)
Affinity DataKi:  0.490nM ΔG°:  -54.0kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17431(1,2,4-Triazole Compound, 89 | N-(5-{[(3,4-difluoro...)
Affinity DataKi:  0.5nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17416(1,2,4-Triazole Compound, 74 | methyl 4-({5-[(3-met...)
Affinity DataKi:  0.5nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17352(1,2,4-Triazole Compound, 6 | 5-(benzylsulfanyl)-N-...)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17385(1,2,4-Triazole Compound, 43 | N-(4-chlorophenyl)-5...)
Affinity DataKi:  0.520nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19808(benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM35042(benzothienopyrimidinone deriv., 18b)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/moleT: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17380(1,2,4-Triazole Compound, 38 | N-(4-chlorophenyl)-5...)
Affinity DataKi:  0.610nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17368(1,2,4-Triazole Compound, 26 | 5-{[(2-fluorophenyl)...)
Affinity DataKi:  0.650nM ΔG°:  -51.9kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM35048(benzothienopyrimidinone deriv., 20c)
Affinity DataKi:  0.700nM ΔG°:  -52.3kJ/moleT: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50408519(CHEMBL115357)
Affinity DataKi:  0.700nMAssay Description:Relative binding affinity was measured for Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17408(1,2,4-Triazole Compound, 66 | methyl 4-{[5-(benzyl...)
Affinity DataKi:  0.700nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17354(1,2,4-Triazole Compound, 12 | N-phenyl-5-[(thiophe...)
Affinity DataKi:  0.75nM ΔG°:  -51.6kJ/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM35043(benzothienopyrimidinone deriv., 19a)
Affinity DataKi:  0.800nM ΔG°:  -51.9kJ/moleT: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50408522(CHEMBL126820)
Affinity DataKi:  0.800nMAssay Description:Relative binding affinity was measured for Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM35050(benzothienopyrimidinone deriv., 20e)
Affinity DataKi:  0.800nM ΔG°:  -51.9kJ/moleT: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17418(1,2,4-Triazole Compound, 76 | methyl 4-[(5-{[(5-me...)
Affinity DataKi:  0.800nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50426461(CHEMBL2322677)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human Cdc7 using biotin-C6linker-TPSDSLIYDDGLS as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM35050(benzothienopyrimidinone deriv., 20e)
Affinity DataKi:  0.900nM ΔG°:  -51.6kJ/moleT: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17405(1,2,4-Triazole Compound, 63 | N-(3,4-dimethoxyphen...)
Affinity DataKi:  0.900nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17413(1,2,4-Triazole Compound, 71 | methyl 4-({5-[(pyrid...)
Affinity DataKi:  0.900nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17414(1,2,4-Triazole Compound, 72 | methyl 4-({5-[(pyrid...)
Affinity DataKi:  0.900nMAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM34997(benzothienopyrimidinone deriv., 6n)
Affinity DataKi:  0.900nM ΔG°:  -51.3kJ/molepH: 7.5 T: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKi: <1nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM35041(benzothienopyrimidinone deriv., 18a)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/moleT: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM35012(benzothienopyrimidinone deriv., 12b)
Affinity DataKi:  1nM ΔG°:  -51.0kJ/molepH: 7.5 T: 2°CAssay Description:In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50408520(CHEMBL126352)
Affinity DataKi:  1nMAssay Description:Relative binding affinity was measured for Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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