PMID

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Article Title

Organization

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.

Astex

Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.

Astex

Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design.

Astex

Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery.

Astex

Application of fragment screening by X-ray crystallography to beta-secretase.

Astex

Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.

Astex

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera.

Astex

Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.

Astex

Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors.

Astex