BDBM50327651 6-Hydroxycoumarin::6-hydroxy-2H-chromen-2-one::CHEMBL243263

SMILES Oc1ccc2oc(=O)ccc2c1

InChI Key InChIKey=CJIJXIFQYOPWTF-UHFFFAOYSA-N

Data  9 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50327651   

TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataKi:  31nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataKi:  34nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataKi:  190nMAssay Description:Inhibition of human carbonic anhydrase 9 catalytic domain by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataKi:  680nMAssay Description:Inhibition of human carbonic anhydrase 12 catalytic domain by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataKi:  2.39E+4nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataIC50:  8.37E+4nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataIC50:  1.71E+5nMAssay Description:Inhibition human recombinant aldose reductase 1 by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSorbitol dehydrogenase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50327651(6-Hydroxycoumarin | 6-hydroxy-2H-chromen-2-one | C...)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibition sorbitol dehydrogenase by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed