BDBM25751 Bisoprolol::Bisoprolol fumarate::Concor::[2-hydroxy-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propyl](propan-2-yl)amine

SMILES CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1

InChI Key InChIKey=VHYCDWMUTMEGQY-UHFFFAOYSA-N

Data  5 KI  4 IC50  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 25751   

TargetBeta-1 adrenergic receptor(Mouse)
Friedrich-Alexander Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]CGP12177 from mouse beta1 adrenoceptor expressed in HEK293T cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-1 adrenergic receptor(Human)
UniversitÄT WÜRzburg

Curated by PDSP Ki Database
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKi:  22.4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetBeta-2 adrenergic receptor(Human)
Friedrich-Alexander Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]CGP12177 from human beta2 adrenoceptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetBeta-2 adrenergic receptor(Human)
Friedrich-Alexander Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKi:  1.15E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetBeta-3 adrenergic receptor(Human)
UniversitÄT WÜRzburg

Curated by PDSP Ki Database
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKi:  9.07E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-2 adrenergic receptor(Human)
Friedrich-Alexander Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKd:  3.30E+4nMAssay Description:Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes assessed as intrinsic Kd by liquid scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetBeta-2 adrenergic receptor(Human)
Friedrich-Alexander Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKd:  150nMAssay Description:Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetBeta-2 adrenergic receptor(Human)
Friedrich-Alexander Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKd:  3.30E+4nMAssay Description:Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes assessed as intrinsic Kd by liquid scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetBeta-2 adrenergic receptor(Human)
Friedrich-Alexander Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKd:  150nMAssay Description:Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-3 adrenergic receptor(Human)
UniversitÄT WÜRzburg

Curated by PDSP Ki Database
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKd:  2.14E+3nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-1 adrenergic receptor(Human)
UniversitÄT WÜRzburg

Curated by PDSP Ki Database
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKd:  15nMpH: 7.4 T: 37°CAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetBeta-2 adrenergic receptor(Human)
Friedrich-Alexander Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM25751(Bisoprolol | Bisoprolol fumarate | Concor | [2-hyd...)
Affinity DataKd:  200nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank