BDBM50300204 (2R)-2-acetylamino-N-benzyl-3-methoxypropanamide::(R)-2-Acetylamino-N-benzyl-3-methoxy-propionamide::(R)-2-acetamido-N-benzyl-3-methoxypropanamide::(R)-N-benzyl 2-acetamido-3-methoxypropionamide::(R)-N-benzyl 2-acetamido-3-methoxypropionamide,::CHEMBL58323::Erlosamide::LACOSAMIDE

SMILES COC[C@@H](NC(C)=O)C(=O)NCc1ccccc1

InChI Key InChIKey=VPPJLAIAVCUEMN-GFCCVEGCSA-N

Data  13 KI  12 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50300204   

TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  331nMAssay Description:Inhibition of human recombinant CA2 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 5B, mitochondrial(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  341nMAssay Description:Inhibition of human recombinant CA5B by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 9(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  353nMAssay Description:Inhibition of human recombinant CA9 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  362nMAssay Description:Inhibition of human recombinant CA1 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 3(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  374nMAssay Description:Inhibition of human recombinant CA3 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 6(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  412nMAssay Description:Inhibition of human recombinant CA6 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 15(Mouse)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  461nMAssay Description:Inhibition of mouse recombinant CA15 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 14(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  473nMAssay Description:Inhibition of human recombinant CA14 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 4(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  525nMAssay Description:Inhibition of human recombinant CA4 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 13(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  1.21E+3nMAssay Description:Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 12(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  3.71E+3nMAssay Description:Inhibition of human recombinant CA12 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 7(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  4.45E+3nMAssay Description:Inhibition of human recombinant CA7 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 5A, mitochondrial(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataKi:  4.57E+3nMAssay Description:Inhibition of human recombinant CA5A by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50:  415nMAssay Description:Binding affinity to rat inactivated voltage-gated Na channel 1.3 expressed in human HEK293 cells by patch-clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50:  182nMAssay Description:Binding affinity to human inactivated voltage-gated Na channel 1.7 expressed in HEK293 cells by patch-clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50:  1.60E+4nMAssay Description:Binding affinity to voltage-gated Na channel 1.8 in Sprague-Dawley rat L4/L5 DRG neurons by patch-clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50:  5.01E+7nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium channel protein type 5 subunit alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50:  5.01E+5nMAssay Description:Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50:  1.82E+5nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50:  5.01E+4nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily E/KQT member 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)
Affinity DataIC50:  2.51E+5nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed