BDBM50373116 MEPTAZINOL::US10231963, Table B.11::US10736890, Compound TABLE B.11::US11534436, Compound Table B.11::US9656961, Example 00128

SMILES CCC1(CCCCN(C)C1)c1cccc(O)c1

InChI Key InChIKey=JLICHNCFTLFZJN-UHFFFAOYSA-N

Data  4 KI  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50373116   

TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent
LigandPNGBDBM50373116(MEPTAZINOL | US10231963, Table B.11 | US10736890, ...)
Affinity DataKi:  32nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent
LigandPNGBDBM50373116(MEPTAZINOL | US10231963, Table B.11 | US10736890, ...)
Affinity DataKi:  32nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent
LigandPNGBDBM50373116(MEPTAZINOL | US10231963, Table B.11 | US10736890, ...)
Affinity DataKi:  32nMAssay Description:The Ki (binding affinity) for μ opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Jour...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent
LigandPNGBDBM50373116(MEPTAZINOL | US10231963, Table B.11 | US10736890, ...)
Affinity DataKi:  32nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University Medicine Greifswald

Curated by ChEMBL
LigandPNGBDBM50373116(MEPTAZINOL | US10231963, Table B.11 | US10736890, ...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent
LigandPNGBDBM50373116(MEPTAZINOL | US10231963, Table B.11 | US10736890, ...)
Affinity DataEC50: >600nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes Pharma Ireland

US Patent
LigandPNGBDBM50373116(MEPTAZINOL | US10231963, Table B.11 | US10736890, ...)
Affinity DataEC50: >600nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Mus musculus (mouse))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50373116(MEPTAZINOL | US10231963, Table B.11 | US10736890, ...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of mouse brain AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Mus musculus (Mouse))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50373116(MEPTAZINOL | US10231963, Table B.11 | US10736890, ...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of mouse serum BChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed