BDBM50216514 4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one::CHEMBL394880::Dimethylenastron::rac-dimethylenastron

SMILES CC1(C)CC(=O)C2C(NC(=S)N=C2C1)c1cccc(O)c1

InChI Key InChIKey=JZSJFUOOGSSKHR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50216514   

TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216514(4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Eg5 ATPase activity expressed in Escherichia coli after 12 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216514(4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human His-tagged Eg5 (1 to 368 residues) assessed as reduction in ATPase activity by Bradford reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216514(4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human Eg5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed