BDBM19151 (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone::Antibiotic FR 901228::CHEMBL343448::Depsipeptide::FK228::Romidepsin

SMILES C\C=C1/NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C

InChI Key InChIKey=OHRURASPPZQGQM-GCCNXGTGSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 19151   

TargetHistone deacetylase 6(Mouse)
University of Southampton

LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  787nMpH: 8.0 T: 37°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 4(Human)
Sichuan University and Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  36nMAssay Description:Inhibition of C-terminal biotin-labelled BCoR/wild-type BCL6 BTB domain (unknown origin) protein-protein interaction by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  1nMAssay Description:Inhibition of HDAC1 by fluorimetric assay in presence of DTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  36nMAssay Description:Inhibition of HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  620nMAssay Description:Inhibition of HDAC6 by fluorimetric assay in presence of DTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of HDAC6 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 4(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  510nMAssay Description:Inhibition of HDAC4 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant HDAC3/NCoR2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant HDAC6 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant HDAC1 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of human recombinant HDAC1 after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  670nMAssay Description:Inhibition of human recombinant HDAC6 after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 4(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  8.67E+3nMAssay Description:Inhibition of human recombinant HDAC4 after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Human)
Graduate School of Life Science and Systems Engineering

Curated by ChEMBL
LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  3.97nMpH: 8.0 T: 37°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed