BDBM50002692 (AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione::(AZT)1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione::1-((2R,4R,5S)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione::1-((2R,4S,5S)-4-(diazoamino)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione::1-((2R,4S,5S)-4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione::1-((2R,4S,5S)-4-azido-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione::1-((2R,4S,5S)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione::1-((2R,5S)-4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione::1-((2S,4R,5R)-4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione::1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione::1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (AZT)::1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (AzddThd, AZT)::1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (N3ddThd)::1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione [AZT]::1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione(3'-azido-2',3'-dideoxythymidine)::1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione(AZT)::1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione(Zidovudine, AZT)::1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione(azidothymidine, AZT)::3'-Azido-3'-deoxy-thymidine::3'-Deoxy-3-azidothymidine::3'-azido-2',3'-dideoxythymidine::3'-azido-thymidine::3'azido-2'3'-dideoxythymidine::3-((2S,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)triaz-1-en-2-ium-1-ide::4-(4-Azido-5-hydroxy-tetrahydro-furan-2-yl)-5-methyl-3H-pyrazine-2,6-dione::AZT::BW-A-509U::BWA509U::CHEMBL129::Retrovir::US10071110, Compound AZT::US11420959, Example AZT::ZIDOVUDINE::azidothymidine::zidovudin::zudovidine

SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O

InChI Key InChIKey=HBOMLICNUCNMMY-XLPZGREQSA-N

Data  10 KI  36 IC50  2 Kd  21 EC50

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 69 hits for monomerid = 50002692   

TargetThymidine kinase, cytosolic(Human)
Michigan Cancer Foundation

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory affect against rabbit thymus thymidine kinase and represented as molt/4F kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetThymidine kinase, cytosolic(Human)
Michigan Cancer Foundation

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibitory affect against rabbit thymus thymidine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetThymidylate kinase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  2.80E+4nMAssay Description:Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidylate kinase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  2.80E+4nMAssay Description:In Vitro inhibition of Thymidine Monophosphatase Kinase of Mycobacterium tuberculosis (TMPKm)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidylate kinase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  2.80E+4nMAssay Description:Competitive inhibition of Mycobacterium tuberculosis TMPK by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUDP-glucuronosyltransferase 2B7(Human)
University of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  1.50E+5nMAssay Description:Uncompetitive substrate inhibition of UGT2B7 in diabetic human kidney microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide form...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUDP-glucuronosyltransferase 2B7(Human)
University of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  1.50E+5nMAssay Description:Uncompetitive substrate inhibition of UGT2B7 in non-diabetic human kidney microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUDP-glucuronosyltransferase 2B7(Human)
University of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  2.00E+5nMAssay Description:Uncompetitive substrate inhibition of UGT2B7 in diabetic human liver microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide forma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUDP-glucuronosyltransferase 2B7(Human)
University of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  2.00E+5nMAssay Description:Uncompetitive substrate inhibition of UGT2B7 in non-diabetic human liver microsomes assessed as reduction in enzyme-mediated zidovudine glucuronide f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(Staphylococcus aureus)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKi:  9.44E+5nMAssay Description:Inhibition of Staphylococcus aureus CCM 885 recombinant thymidine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnvelope glycoprotein gp160(HIV-1)
Chimerix

US Patent
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:The in vitro antiviral activity profile for CMX157 was evaluated for cell-type effects and HIV strain effects. It is active against all major subtype...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound was evaluated for enzymatic inhibitory activity against recombinant HIV reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant reverse transcriptase (RT) in cell-free Quan-T-RT assay systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  10nMAssay Description:Tested for the inhibition of the compound towards HIV-reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  30nMAssay Description:Ability to inhibit the HIV-1 reverse transcriptase in cord blood mononuclear cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Tosoh

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory effect of the compound on HIV-1 RT activity using template primer,poly (rA)-oligo (dT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  11nMAssay Description:antiviral activity in Human immunodeficiency virus-1 as reverse transcriptase activity in culture supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration of the compound against human immunodeficiency virus type 1 (HIV-1 strain IIIB RT) reverse transcriptase was determined by t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration of the compound against human immunodeficiency virus type 1 (HIV-1 strain IIIB RT) reverse transcriptase was determined by t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Reverse transcriptase activity was measured in the culture supernatant, concentration that reduces by 50% the HIV produced in the supernatant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Tosoh

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  6nMAssay Description:Inhibitory effect of the compound on HIV-1 RT activity using template primer,poly (rA)-oligo (dT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  3.10nMAssay Description:Antiviral activity against Human Immunodeficiency Virus by Reverse transcriptase assay in CEM-SS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Tosoh

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  126nMAssay Description:Inhibitory activity against HIV-1 IIIB in CEM-SS infected cells(Experiment 1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Hebei University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of HIV-1 reverse transcriptase after 1 hr by ELISA plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlbumin(Human)
Mercer University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataKd:  4.40E+4nMAssay Description:Binding affinity to human serum albumin with excitation at 280 nm after 2 hrs by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetReverse transcriptase(Human immunodeficiency virus type 1)
Hebei University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  2.01E+4nMAssay Description:Inhibition of HIV1 reverse transcriptase using DIG-labeled dNTPs as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein kinase C beta type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of PKC beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProtein kinase C epsilon type(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of PKC epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDNA polymerase beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(Ureaplasma parvum)
Swedish University Agricultural Sciences

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of Ureaplasma parvum thymidine kinase by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase, cytosolic(Human)
Michigan Cancer Foundation

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human TK1 by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetC-X-C chemokine receptor type 4(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  7.90nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  10nMAssay Description:Effective concentration that reduces HIV-induced cytopathic effect by 50% was determined by reverse transcriptase (RT) assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50:  40nMAssay Description:Concentration required to inhibit HIV reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  2.49E+4nMAssay Description:Tested in vitro against HIV-1 MDR using MAGI assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  38nMAssay Description:Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  8nMAssay Description:Antiviral activity against HIV1 IRLL98 in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Antiviral activity against wild type HIV1 NL4-3 in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Antiviral activity against HIV1 K103N mutant in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Antiviral activity against HIV1 Y188L mutant in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Effective concentration in vitro agaianst HIV-1-infected CEM cells relative to uninfected untreated controlsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetC-X-C chemokine receptor type 4(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  48nMAssay Description:Inhibition of HIV-induced cytopathogenicity in MT-4 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Effective concentration required to inhibit HIV-1 induced cytopathicity by 50% in CEM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  2nMAssay Description:Effective concentration required to achieve 50% inhibition of HIV-1 LAI replication in human T4 lymphoblastoid CEM-SS cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


TargetHIV-1 protease(Human immunodeficiency virus)
The Regents of The University of California

US Patent
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  7nMAssay Description:Preliminary experiments in the inhibition of HIV-1 replication by invention compounds were performed as follows. Drug assays were carried out as prev...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Institute

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: <100nMAssay Description:Inhibition of HIV-1 reverse transcriptase from peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank


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