BDBM295989 4-{4-[2-(2H- 1,3-benzodioxol- 5-yl)pyrrolidine- 1-carbonyl]-2- methoxyphenyl}- 1H-pyrazole::US10112939, Example 30

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)N1CCCC1c1ccc2OCOc2c1

InChI Key InChIKey=HBRFUVJOZLFFCL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 295989   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 295989BDBM295989(US10112939, Example 30 | 4-{4-[2-(2H- 1,3-benzodio...)
Affinity DataIC50: 75.3nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent